Exploring Microbial Communication

Publications

Here you can find publications Professor Fihn and his group.

Highlighted

Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa
Conrad A. Fihn, Hannah K. Lembke, Jeffrey Gaulin, Patricia Bouchard, Alex R. Villarreal, …, Michael H. Serrano-Wu, Nathalie Drouin, Deborah T. Hung, Ryan C. Hunter, Erin E. Carlson
Bioorganic Chemistry  ·  01 Dec 2024  ·  doi:10.1016/j.bioorg.2024.107840
Structure-activity relationship study of 2-aminobenzothiazole histidine kinase inhibitors and antivirulence compounds against Pseudomonas aeruginosa.
pseudomonas antivirulence medicinal-chemistry

All

2026

A high-throughput biocatalytic platform for screening isomeric kainoid natural products
A high-throughput biocatalytic platform for screening isomeric kainoid natural products
Robert A. Shepherd, Manasa Ramachandra, Austin R. Hopiavuori, Melanie C. Jones, Conrad A. Fihn, …, Ananya Manjunath, Limar Y. Gad, Chloe R. Whipple, Shaun M.K. McKinnie, Laura M. Sanchez
Cell Reports Physical Science  ·  01 Feb 2026  ·  doi:10.1016/j.xcrp.2025.103092
Using Untargeted Mass Spectrometry Based Proteomics to Identify Putative Microprotein Biomarkers from Patient Tampons
Using Untargeted Mass Spectrometry Based Proteomics to Identify Putative Microprotein Biomarkers from Patient Tampons
G. T. Luu, C. A. Fihn, L. M. Sanchez
Methods in Molecular Biology  ·  01 Jan 2026  ·  [no id info]
proteomics mass-spectrometry microbiology
Development of covalent inhibitors for bacterial histidine kinases
Development of covalent inhibitors for bacterial histidine kinases
Patricia D. Rodriguez, Conrad A. Fihn, Manibarsha Goswami, Erin E. Carlson
Chemical Communications  ·  01 Jan 2026  ·  doi:10.1039/D5CC06657C

2025

Using Untargeted Mass Spectrometry-Based Proteomics to Identify Putative Microprotein Biomarkers from Patient Tampons
Using Untargeted Mass Spectrometry-Based Proteomics to Identify Putative Microprotein Biomarkers from Patient Tampons
Gordon T. Luu, Conrad Fihn, Laura M. Sanchez
Methods in Molecular Biology  ·  17 Nov 2025  ·  doi:10.1007/978-1-0716-5013-4_20
A High-Throughput Biocatalytic Platform for Screening Isomeric Kainoid Natural Products
A High-Throughput Biocatalytic Platform for Screening Isomeric Kainoid Natural Products
Robert A. Shepherd, Manasa Ramachandra, Austin R. Hopiavuori, Melanie C. Jones, Conrad A. Fihn, …, Ananya Manjunath, Limar Y. Gad, Chloe R. Whipple, Shaun M. K. McKinnie, Laura M. Sanchez
openRxiv  ·  12 Sep 2025  ·  doi:10.1101/2025.09.07.674781
Need for speed: high throughput mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes
‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes
Robert A. Shepherd, Conrad A. Fihn, Alex J. Tabag, Shaun M. K. McKinnie, Laura M. Sanchez
Natural Product Reports  ·  01 Jan 2025  ·  doi:10.1039/D4NP00053F

2024

Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa
Conrad A. Fihn, Hannah K. Lembke, Jeffrey Gaulin, Patricia Bouchard, Alex R. Villarreal, …, Michael H. Serrano-Wu, Nathalie Drouin, Deborah T. Hung, Ryan C. Hunter, Erin E. Carlson
Bioorganic Chemistry  ·  01 Dec 2024  ·  doi:10.1016/j.bioorg.2024.107840
Structure-activity relationship study of 2-aminobenzothiazole histidine kinase inhibitors and antivirulence compounds against Pseudomonas aeruginosa.
pseudomonas antivirulence medicinal-chemistry

2022

High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications
High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications
Andrew N. Murtha, Misha I. Kazi, Richard D. Schargel, Trevor Cross, Conrad Fihn, Vincent Cattoir, Erin E. Carlson, Joseph M. Boll, Tobias Dörr
PLOS Pathogens  ·  07 Feb 2022  ·  doi:10.1371/journal.ppat.1010307
antibiotic-tolerance microbiology

2021

Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity
Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity
Conrad A Fihn, Erin E Carlson
Current Opinion in Microbiology  ·  01 Jun 2021  ·  doi:10.1016/j.mib.2021.03.007
Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity
Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity
Michael Haenisch, Tai Nguyen, Conrad A. Fihn, Alex S. Goldstein, John K. Amory, Piper Treuting, Thea Brabb, Jisun Paik
International Journal of Obesity  ·  01 May 2021  ·  doi:10.1038/s41366-021-00818-1
Investigation of an ALDH1A1-Specific Inhibitor for Suppression of Weight Gain in a Diet-Induced Mouse Model of Obesity
Investigation of an ALDH1A1-Specific Inhibitor for Suppression of Weight Gain in a Diet-Induced Mouse Model of Obesity
M. Haenisch, T. Nguyen, C. A. Fihn, A. S. Goldstein, J. K. Amory, P. Treuting, T. Brabb, J. Paik
International Journal of Obesity  ·  01 Jan 2021  ·  [no id info]
metabolism obesity-biology

2018

Screening serine threonine and tyrosine kinase inhibitors for histidine kinase inhibition
Screening serine/threonine and tyrosine kinase inhibitors for histidine kinase inhibition
Kaelyn E. Wilke, Conrad A. Fihn, Erin E. Carlson
Bioorganic & Medicinal Chemistry  ·  01 Oct 2018  ·  doi:10.1016/j.bmc.2018.04.047
Screening Serine Threonine and Tyrosine Kinase Inhibitors for Histidine Kinase Inhibition
Screening Serine/Threonine and Tyrosine Kinase Inhibitors for Histidine Kinase Inhibition
K. E. Wilke, C. A. Fihn, E. E. Carlson
Bioorganic & Medicinal Chemistry  ·  01 Jan 2018  ·  [no id info]
histidine-kinases kinase-inhibitors chemical-biology

2014

Directed Polyvalent Display of Sulfated Ligands on Virus Nanoparticles Elicits Heparin-Like Anticoagulant Activity
Directed Polyvalent Display of Sulfated Ligands on Virus Nanoparticles Elicits Heparin-Like Anticoagulant Activity
Griffin Mead, Megan Hiley, Taryn Ng, Conrad Fihn, Kevin Hong, Myles Groner, Walker Miner, Daniel Drugan, William Hollingsworth, Andrew K. Udit
Bioconjugate Chemistry  ·  10 Jul 2014  ·  doi:10.1021/bc500200t
bioconjugate-chemistry nanoparticles